Abstract #5317

The effects of illness duration on white matter connectivity in drug-naive schizophrenia

Fei Li¹, Su Lui¹, Li Yao¹, Wei Liao², Gongjun Ji³, Xiaoqi Huang¹, and Qiyong Gong¹

¹Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, ²Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China, ³Laboratory of Cognitive Neuropsychology, Department of Medical Psychology, Anhui Medical University, Hefei, China

This study investigated the topological alterations of white matter connectivity in schizophrenia patients with a long illness duration by using diffusion tensor imaging and graph theoretical analysis and explored the relationship of such characteristics with the duration. We recruited three groups including the healthy controls, drug-naive schizophrenia patients with a short illness duration (0.1 to 10 months) and a long duration (12 to 36 months), and found that only the patients with a long illness duration exhibited decreased connection strength than the controls and a correlation between the nodal degree of rolandic operculum and the duration, suggesting a neuroprogressive process.

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