Analysis of resting-state networks alterations of first-episode obsessive–compulsive disorder by ICA -based fMRI

Whole brain resting-state functional connectivity was analyzed using independent component analysis in 47 subjects including 23 first-episode and treatment-naïve patients with obsessive-compulsive disorder（OCD） and 24 health controls. Three abnormal resting-state networks, pDMN, RFP and lVN, have been found in OCD patients. In addition, OCD patients showed increased functional connection in Bilateral cuneus（T=3.8222，P=0.005）, Right inferior parietal lobule（T=5.291，P=0.005）and Right middle occipital lobule(T=4.614，P=0.005） compared with controls. It’s considered that changes of abnormal resting-state networks might be associated with emotional and cognitive dysfunction in OCD patients.