Abstract #5296

Brain Metabolism in Schizophrenia and First-Degree Relatives: a 7T MRS study

Anna Min Wang^1,2, Subechhya Pradhan^1,2, Stephanie Korenic³, S. Andrea Wijtenburg³, Laura M. Rowland³, and Peter B. Barker^1,2

¹Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Kennedy Krieger Institute, Baltimore, MD, United States, ³Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United States

Brain metabolism was investigated in 38 patients with schizophrenia (SZ), 38 healthy control (HC) subjects, and 11 first degree relatives of SZ patients using 7T MRS in 5 brain regions. Multiple metabolic abnormalities were found in SZ patients, including increases in the ratio of glutamine to glutamate, increased levels of brain lactate, and decreased levels of γ-aminobuytric acid (GABA) and N-acetylaspartate-glutamate (NAAG). Many of these changes also correlated with measures of cognitive performance and negative symptom severity. 7T MRS is an excellent tool for the non-invasive investigation of brain pathophysiology in SZ.

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