Abstract #5291

Multicenter assessment of focal and diffuse cervical cord MTR abnormalities in early relapsing-remitting multiple sclerosis

Benoit Combès¹, Anne Kerbrat^1,2, Laureline Monteau³, Jean-Christophe Ferré^1,3, Emmanuelle Le Page², Josefina Maranzano⁴, Virginie Callot⁵, Pierre Labauge⁶, Xavier Ayrignac⁶, Clarisse Carra Dallière⁶, Nicolas Menjot de Champfleur⁶, Jean Pelletier⁷, Adil Maarouf⁷, David Brassat⁸, Jérome de Seze⁹, Nicolas Collongues⁹, Francoise Durand Dubief ¹⁰, Christian Barillot¹, Gilles Edan², and Elise Bannier^1,3

¹Univ Rennes, Inria, CNRS, Inserm, IRISA UMR 6074, VISAGES ERL U-1228, F-35000, Rennes, France, ²Neurology department, Rennes University Hospital, Rennes, France, ³Radiology department, Rennes University hospital, Rennes, France, ⁴MNI, Montréal, Canada, Montreal, QC, Canada, ⁵CRMBM UMR7339, Aix-Marseille University, CNRS, Marseille, France, ⁶Montpellier University Hospital, Montpellier, France, ⁷APHM, La Timone Hospital, Marseille, France, ⁸Toulouse University Hospital, Toulouse, France, ⁹Strasbourg University Hospital, Strasbourg, France, ¹⁰Lyon University Hospital, Lyon, France

The purpose of this work was to assess the ability of magnetization transfer ratio imaging of the cervical spinal cord to capture relevant differences in the first stage of multiple sclerosis in a multicenter context. For this purpose, we analyzed the MTR values in the lesions, the whole cord and normal-appearing cord from 52 patients in the first 18 months of the disease and from 17 controls. Images were acquired in 5 centers. We showed such measurements were able to capture relevant group differences and displayed slightly higher correlations with patients clinical status than lesion volume.

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