Abstract #5278

1H MRS study of glutamate excitotoxicity in hypothalamus of early multiple sclerosis patients

Petra Hnilicová¹, Ema Kantorová², Hubert Poláček ³, Štefan Sivák², Michal Bittšanský¹, Kamil Zeleňák⁴, Egon Kurča², and Dušan Dobrota ⁵

¹Division of Neurosciences, Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia, ²Clinic of Neurology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia, ³Clinic of Nuclear Medicine, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia, ⁴Clinic of Radiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia, ⁵Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia

Multiple sclerosis (MS) is considered as an autoimmune disease with expanding axonal and neuronal degeneration in the spinal cord or cerebral cortex during the acute MS phase. The hypothalamus (HYP) is often overlooked yet controls important homeostatic functions. This ¹H MRS study performed on 1.5 T MR scanner using 3D CSI with 10×10×12.5 mm³ voxels was focused to altered HYP metabolism in early MS. Considering our results, increased Glx ratios with reduced mIns and tNAA ratios in HYP suggested glutamate excitotoxicity associated with glial activity and neuronal damage. This indicated that HYP plays an important role in early disease evolution.

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