Imaging of cortical demyelination in chronic multiple sclerosis, has been challenging. Previous MRI studies have detecting signal changes in cortical lesions have been attributed to myelin loss and the presence of iron-laden microglia. Here we demonstrate, in a case study, that MR microscopy may readily identify individual iron-rich cells (primarily oligodendrocytes) and regions. In addition, MR microscopy is shown to allow detailed examination of the central vein signal in white matter lesions.
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