Abstract #5273

Surface-based Quantitative Susceptibility Mapping of Cortical Pathology in Multiple Sclerosis

Marco Castellaro^1,2, Roberta Magliozzi^2,3, Alessandro Palombit¹, Stefania Montemezzi⁴, Francesca Benedetta Pizzini⁴, Alessandra Bertoldo¹, and Massimiliano Calabrese²

¹Department of Information Engineering, University of Padova, Padova, Italy, ²Department of Neurological, Biomedical and Movement Sciences, University of Verona, Verona, Italy, ³Faculty of Medicine, Imperial College London, London, United Kingdom, ⁴University of Verona, Verona, Italy

Multiple Sclerosis has been showed to be characterized by extent cortical sub-pial demyelination and iron alterations. Moreover, a “surface-in” gradient of pathology has been showed to be present in MS. In this study, we used QSM to investigate iron and/or myelin changes in the whole cortex. Moreover, we exploit surface-based methods to clarify the presence of a laminar specific changes in cortical susceptibility of Relapsing-Remitting MS patients.

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