Abstract #5268

Early Apparent Diffusion Coefficient Deficit Correlates to Final Outcome in Experimental Neonatal Hypoxic Ischemia

Yu-Chieh Jill Kao^1,2, Chia-Feng Lu^1,3, Chao-Ching Huang^4,5, and Cheng-Yu Chen^1,2

¹Research Center of Translational Image, Teipei Medical University, Taipei, Taiwan, ²Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ³Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ⁴Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ⁵Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan

Changes in apparent diffusion coefficient (ADC) at 2 h after hypoxic ischemia (HI) in neonatal rats showed the significant correlation to the final lesion severity. The early ADC deficit appeared within 6 h after HI injury may serve as an index for outcome prediction and the translational evidence to stratify neonates for hypothermia treatment.

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