In this large sample retrospective study of MS patients with different diagnoses and treatment regimens we investigated interactions between imaging metrics and age, MS phenotype, and types of treatment, and longitudinal changes associated with disease modifying treatments. We assessed WM injury using DTI metrics (FA, MD), and vascular changes (CBF and CBV) using perfusion DSC, in corpus callosum and in its cortical projections. We found significant correlations of perfusion with age, and DTI metrics with disease type and medication, suggesting that advanced neuroimaging methods such as DTI should become integrated into the clinical evaluation of MS patients for improved management.
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