Abstract #5211

Personalized Lesion Profiling in Multiple Sclerosis

Sidong Liu^1,2, Alexander Klistorner^1,2,3, Chenyu Wang^1,4, Yang Gao⁵, Brittany Gilchrist^2,3, Yang Song⁶, Yuyi You², Junen Yao⁵, Weidong Cai⁶, and Michael Barnett^1,4

¹Brain and Mind Centre, University of Sydney, Sydney, Australia, ²Save Sight Institute, University of Sydney, Sydney, Australia, ³Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia, ⁴Sydney Neuroimaging Analysis Centre, Sydney, Australia, ⁵School of Instrumentation Science and Opto-Electronics Engineering, Beihang University, Beijing, China, ⁶School of Information Technologies, University of Sydney, Sydney, Australia

The pathology of multiple sclerosis (MS) lesions is highly subject-specific, therefore personalized lesion analysis is important in assessing the degree of disease-related brain damage and the patient’s response to therapy. Separating and comparing lesional and non-lesional tissue provides an “internal control” and, therefore, increased precision of measurement of the degree of lesional damage in the brain. Here we present a novel and fully automatic method to create a personalized lesion profile of the subject based on DTI tractography, which can be used to assess whole brain lesional damage. This technique can be applied to measure microstructural change using any MRI modality, and may have high translational impact in clinical trials and neurological research.

This abstract and the presentation materials are available to members only; a login is required.

Join Here