Balanced SSFP (bSSFP) has been used as a new alternative for water-fat separation imaging due to its fast acquisition and high SNR efficiency. However, it displays characteristic banding artifacts in the presence of field inhomogeneity, especially at the 7T ultrahigh-field MRI system. Complex combination of two phase-cycled bSSFP was used to alleviate the artifact at 3T, but would take more scan time. Integrated SSFP (iSSFP), which was modified from bSSFP, was introduced to separate water and fat while removing banding artifacts in shorter scan time. iSSFP also inherited the advantages of relatively high SNR and bright fluid. 3D iSSFP with high spatial resolution may have great potential to separate water and fat in the clinical application of 7T ultrahigh-field MRI.
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