Abstract #5167

Quantitative Dynamic Contrast-enhanced MR Imaging in Different Arterial Input Functions and Measurement Dimensions: Which Method Performs Best in differentiation of Malignant from Benign Soft Tissue Tumors?

Jimin Yoon¹, Won-Hee Jee¹, Jun-Pyo Myoung², Joon-Yong Jung¹, Chan Kwon Jung³, and Yang-Guk Chung⁴

¹Radiology, Seoul St. Mary’s Hospital, School of Medicine, The Catholic University of Korea, Seocho-gu, Republic of Korea, ²Occupational and environmental medicine, Seoul St. Mary’s Hospital, School of Medicine, The Catholic University of Korea, Seocho-gu, Republic of Korea, ³Pathology, Seoul St. Mary’s Hospital, School of Medicine, The Catholic University of Korea, Seocho-gu, Republic of Korea, ⁴Orthopedics, Seoul St. Mary’s Hospital, School of Medicine, The Catholic University of Korea, Seocho-gu, Republic of Korea

This study was designed to evaluate the reliability of quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) according to the different arterial input functions (AIF) at different measurement dimensions in differentiating malignant from benign soft tissue tumors at 3T. Quantitative DCE-MRI parameters of either benign or malignant tumors were obtained in three different measurement dimensions: focal early enhancing area, single-slice average, and whole tumor volume. They were calculated using three different population-averaged AIF (fast, intermediate and slow) and one of the three AIF of the lowest Chi-square, using SyngoVia software. The result showed quantitative DCE-MRI may be reliable and accurate in differentiating malignant from benign soft tissue tumors at 3T, particularly from focal early enhancing area using intermediate or fast AIF.

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