The measurement of vertebral bone marrow triglyceride unsaturation using single-voxel STEAM MRS serves as a potential biomarker for bone health. The required quantifiction of the olefinic fat peak (OFP) is often prevented by an overlapping water signal. The aim of this study was to investigate the feasibility of measuring the OFP by defining a quantification reliability measure (QRM) based on the comparison of two constrained triglyceride models. Result: The feasibility of estimating the OFP depends on the water linewidth and proton density fat fraction, increases with the QRM and may not be achievable if the water peak and OFP are not intercepting.
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