In this study, the altered microcirculation and oxygenation of skeletal muscle in T2DM rhesus monkeys were evaluated by non-contrast skeletal muscle MR perfusion and oximetry techniques. We found that the perfusion of skeletal muscle decreased, especially in fast-twitch fiber muscles, and with an air-cuff caused muscle hyperemia, the ability to reperfusion in slow-twitch muscle is higher than in fast-twitch muscle. The oxygen extraction fraction of skeletal muscle significantly increased in all skeletal muscle angiosomes. These results suggest the diverse adaptation of slow- and fast-twitch skeletal muscles to T2DM.
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