Abstract #5126

Improved quantification of amide proton transfer effect with direct water saturation- and magnetization transfer-correction in a glioma rat model at 3 Tesla

Yin Wu¹, Yinsheng Chen², Yiying Zhao², Shasha Yang¹, Jing Zhao¹, Zhongping Chen², and Phillip Zhe Sun³

¹Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ²Department of Neurosurgery, Cancer Center, Sun Yat-Sen University, Guangzhou, China, ³Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States

Quantification of in vivo APT effect with routine asymmetry analysis is problematic due to concomitant contributions. Herein, a steady-state CEST signal solution was utilized to estimate direct water saturation (DWS) to improve Z-spectral quantification in a pulsed-RF CEST imaging. Specifically, APT effect was measured from the DWS and magnetization transfer (MT)-corrected CEST signals in glioma rat brains post-chemoradiotherapy at 3 Tesla. The proposed method revealed significant APT signal difference among regions of control (3.13±0.38%), necrosis (3.95±0.31%) and tumor (4.56±0.34%), consistent with histological observations and superior than routine asymmetry analysis.

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