Abstract #5121

In vivo Kinetic CEST MRI of sodium salicylate(NaSA): Comparison of MTRasym and Subtraction of saturation-weighted images

Yanrong Chen^1,2, Chengwang Jin^1,3, Yan Luo⁴, Chongxue Bie², Yingcheng Zhao², Xiaowei He², and Xiaolei Song¹

¹The Johns Hopkins University, Baltimore, MD, United States, ²School of Information and Technology, Northwest University, Xi'an, China, ³Medical Imaging, The First affiliated Hospital of Xian Jiaotong University, Xi'an, China, ⁴Radiology Department Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Salicylate analogues feature chemical shift far from water (Δω = 8-10 ppm), however, there are almost no available reports on their in vivo detection of salicylate upon intravenous administration. We aim to optimize the in vivo detection of NaSA, by comparing compared MTRasym and a Dynamic Salicylate Enhancement (DSE). For the mice brain with LPS-induced inflammation, there are ~4% DSE signal which displays a clear kinetic trend. While MTRasm values are very small, oscillating between -2% to 0% due to the unsymetric MTC. In conclusion, our DSE method is able to track the dynamic signal changes following the infusion of NaSA.

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