Abstract #5077

Drug efficacy monitoring using magnetic resonance imaging in a cancer cachexia model

Ho-jin Kim¹, Sun Kyu Park², Jeom Yong Kim², Chul-Woong Woo³, Sang-Tae Kim³, Kyung Won Kim⁴, and Dong-Cheol Woo^5,6

¹Department of Biomedical Sciences, Asan Institute for Life Sciences, Asan medical center, University of Ulsan College of Medicine, Seoul, Republic of Korea, ²Green Cross WellBeing Coporation, Seongnam, Gyeonggi-do, Republic of Korea, ³MR Core Laboratory, Asan Institute for Life Sciences, Asan medical center, Seoul, Republic of Korea, ⁴Department of Radiology, Asan medical center, University of Ulsan College of Medicine, Seoul, Republic of Korea, ⁵MR Core Laboratory, Asan Institute for Life Sciences, Asan medical center, University of Ulsan College of Medicine, Seoul, Republic of Korea, ⁶Department of Convergence Medicine, Asan medical center, University of Ulsan College of Medicine, Seoul, Republic of Korea

Most studies in the field of cachexia research show photographs and H&E-stained sections of hindlimb muscles to demonstrate changes in fat/muscle volume. However, these methods do not capture the global changes in fat/muscle volume in a cachexia model.

In this study, we established a cachexia animal model induced by tumor and ant-cancer drug and examined the efficacy of an anticachexia drug by monitoring fat/muscle volume using magnetic resonance imaging (MRI). Our results illustrated that MRI is a useful tool for drug development owing to its ability to monitor fat/muscle volumes in the cachexia model.

This abstract and the presentation materials are available to members only; a login is required.

Join Here