Abstract #5049

Optimizing $$$T_{1\rho}$$$ dispersion measurements for correlation time mapping in articular cartilage at 9.4 T

Hassaan Elsayed^1,2,3, Stefan Zbyn^1,2,3, Nina Hänninen¹, Timo Liimatainen⁴, Mikko J. Nissi⁵, Miika T. Nieminen^1,2,3, and Matti Hanni^1,2,3

¹Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, ²Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland, ³Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland, ⁴Clinical Imaging Center, Kuopio University Hospital, Kuopio, Finland, ⁵Department of Applied Physics, University of Eastern Finland, Kuopio, Finland

Correlation time ($$$\tau_c$$$) is an intrinsic property of molecules that can be probed from $$$T_{1\rho}$$$ dispersion measurement. The aim of this study was to evaluate the effect of low and high spin-lock frequencies (SLFs) on $$$\tau_c$$$ fitting and to find the optimum SLFs set within the typical clinical range. One bovine and two human cartilage samples were scanned to obtain $$$T_{1\rho}$$$ dispersion with 22 SLFs between 10 to 2500 Hz. $$$\tau_c$$$ maps were obtained by fitting Lorentzian function to different subsets of $$$T_{1\rho}$$$ dispersion. Our results show that $$$\tau_c$$$ fitting is significantly affected by low SLFs compared to high SLFs.

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