Abstract #5038

Compositional assessment of low-grade cartilage lesions using T2 mapping at 3 and 7 Tesla MRI: a one year follow-up study

Vladimir Juras^1,2, Markus Schreiner³, Didier Laurent⁴, Stefan Zbyn⁵, Vladimir Mlynarik¹, Pavol Szomolanyi¹, Celeste Scotti⁴, Joerg Goldhahn⁴, Harry Haber⁴, Ewa Kubiak⁴, Stefan Marlovits⁶, Rahel Heule⁷, Oliver Bieri⁷, Ivan Frollo⁸, and Siegfried Trattnig^1,9

¹Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, ²Department of Imaging Methods, Institute of Measurement Science, Bratislava, Slovakia, ³Department of Orthopedics, Medical University of Vienna, Vienna, Austria, ⁴Novartis Institutes for Biomedical Research, Basel, Switzerland, ⁵Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, ⁶Department of Traumatology, Medical University of Vienna, Vienna, Austria, ⁷Division of Radiological Physics, Department of Radiology, University of Basel Hospital, Basel, Switzerland, ⁸Slovak Academy of Sciences, Institute of Measurement Science, Bratislava 4, Slovakia, ⁹Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria

T2 maps were assessed as a potential marker for the long-term follow-up of the patients with cartilage lesions ICRS Grade I-II in five time points (baseline, 8 days, 3, 6 and 12 months). For the T2 mapping, a 3D triple echo steady state sequence which is capable of delivering high quality high-resolved T2 maps at ultra-high field MRI was used. We observed a significant decrease in T2 values at 3T over time in superficial zone of the cartilage defect. There was no statistically significant change at 7T. T2 mapping could be used in the future as a good alternative to cartilage biopsies in clinical trials on new therapies aimed at cartilage regeneration.

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