Abstract #5021

Nanomicelles – A Blood Pool Contrast Agent for MRI

Vassily Vorobiev¹, Lindsey Alexandra Crowe², Yohan van de Looij^3,4,5, Lothar Helm⁶, Samuel Espy¹, Andrej Babič¹, Jean-Paul Vallée², and Eric Allémann¹

¹School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland, ²Division of Radiology, Geneva University Hospitals, Geneva, Switzerland, ³Institut Translationnel d'Imagerie Moléculaire, University of Geneva, Geneva, Switzerland, ⁴Service Développement et Croissance, University of Geneva, Geneva, Switzerland, ⁵Laboratoire d'Imagerie Fonctionnelle et Métabolique, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ⁶Group of Inorganic and Bioinorganic Chemistry, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

A blood pool MRI contrast agent for free breathing MR angiography is highly desirable in particular for pediatric cardiovascular exams in order to improve both image quality and patient comfort. Apnea in infants and be propofol induced, or via intubation, which is invasive and limits acquisition to short protocols. We present here initial in-vivo studies in mice of a newly developed nanomicelles gadolinium contrast agent. Persistent vascular enhancement is observed with no toxicity. Micelles also open the way to functionalization for theranostic applications.

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