We present a method for 3D non-rigid, feature-based atlas registration to images that contain limited inherent anatomical MR contrast. This method can be used to standardize ROI identification and may be applied to any multi-functional imaging technique to provide increased quantitative registration accuracy. Here quantitative T1 measurements were used to test the accuracy and reproducibility of the method. Overall, data analysis performed with atlas registration provides a 2-fold reduction in standard deviation and 4-fold increase in reproducibility versus data analysis performed without registration.
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