Abstract #5005

Imaging Human Brain Cortical Substructure with Quantitative Susceptibility Mapping at 7 T

Hongjiang Wei¹, Berkin Bilgic², Kawin Setsompop², Boris Keil², David Feinberg ^3,4, and Chunlei Liu^1,3

¹EECS, University of California, Berkeley, Berkeley, CA, United States, ²Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ³Helen Wills Institute for Neuroscience, University of California, Berkeley, Berkeley, CA, United States, ⁴Advanced MRI Technologies, Sebastopol, CA, United States

High-field MRI combined with high-density motor-cortex coil and a novel QSM algorithm allows in vivo brain cortex imaging with high contrast-to-noise ratio and spatial resolution (0.15x0.15x0.65 mm³). Our work revealed up to six apparent myelin/iron layers in human cortex in vivo determined by the underlying magnetic susceptibility and complex vasculature in the cortical areas. Cortical susceptibility imaging provides high-resolution quantitative measurements of cortical cytoarchitecture and vasculature.

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