Previous imaging studies reported iron-induced T2* or phase contrast changes in the cortex of post-mortem brain tissue of patients with Alzheimer’s disease (AD), but comparison with a gold standard is lacking. This study used laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) as a gold standard for iron in post-mortem brain tissue of controls and AD patients and investigated the correlation between LA-ICP-MS, quantitative MRI (R2*, phase, and QSM) and histology. R2* and QSM showed the highest correlation with iron content; the correlation of phase with iron was weaker, probably due to its high orientation dependence.
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