Abstract #4980

Longitudinal assessment of TAT-PHP treatment effect in improving brain function recovery from cardiac arrest resuscitation with endogenous perfusion using ASL and metabolic CEST MRI

Rong-Wen Tain^1,2,3, Chunpei Lee⁴, Alessandro Scotti^2,3,5, Weiguo Li^6,7, Xiangdong Zhu⁴, Terry L. Vanden Hoek⁴, Jing Li⁴, and Kejia Cai^2,3,5

¹Campus Center for Neuroimaging, University of California, Irvine, CA, United States, ²Radiology, College of Medicine, University of Illinois, Chicago, IL, United States, ³3T Research Program, Center for MR Research, College of Medicine, University of Illinois, Chicago, IL, United States, ⁴Emergency Medicine, College of Medicine, University of Illinois, Chicago, IL, United States, ⁵Bioengineering, College of Engineering, University of Illinois, Chicago, IL, United States, ⁶Research Resource Center, University of Illinois, Chicago, IL, United States, ⁷Radiology, Northwestern University, Chicago, IL, United States

Sudden cardiac arrest is a leading cause of death in the US. A recently developed peptide-based (TAT-PHP) therapy has been shown to improve survival rate and heart metabolism in animal studies. There is a great need to evaluate the effect of the treatment in the brain as the brain is the most susceptible organ following cardiac arrest. We here demonstrated that the recovery of brain perfusion and metabolism is improved in mice with TAT-PHP treatment vs. controls with endogenous perfusion arterial spin labeling MRI and metabolic MRI based on chemical exchange saturation transfer.

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