Abstract #4938

Effects of Track Length on White Matter Alterations in Mild Traumatic Brain Injury

Sourajit Mitra Mustafi¹, Jaroslaw Harezlak², Joaquin Goni³, Laura A Flashman⁴, Thomas W McAllister⁵, and Yu-Chien Wu¹

¹Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, ²Department of Epidemiology and Biostatistics, Indiana University, School of Public Health, Bloomington, IN, United States, ³College of Engineering, Purdue University, West Lafayette, IN, United States, ⁴Department of Psychiatry, Dartmouth-Hitchcock Medical Center and Geisel School of Medicine, Hanover, NH, United States, ⁵Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, United States

In the present study, we performed streamline tractography to characterize effects of track length on white-matter microstructural alterations after mild traumatic brain injury. Streamline length and counts were studied in involved white-matter fiber tracts that were found to have decreased axonal density at some points along the tracts using voxel-based analyses. The results suggested that long fibers in the brains of individuals who sustained mild traumatic brain injury are more vulnerable to the injury.

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