Abstract #4934

MR susceptometry based superior sagittal sinus venous oxygen saturation: effects of carbon dioxide based cerebral vascular reserve and anesthesia in Moyamoya patients

Chou-Ming Cheng^1,2, Tzu-Chen Yeh^3,4, Jen-Chuen Hsieh^2,4, and Hsiao-Wen Chung¹

¹Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, ²Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ³Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan, ⁴Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan

Venous oxygen saturation (SvO₂) is measured on Moyamoya patients with previous proposed automatic methods based on MR susceptometry from the phase information obtained with multi-echo gradient-echo imaging. According to anesthesia condition and carbon dioxide based cerebral vascular reserve (CO₂-CVR) using blood oxygen level dependence (BOLD) technique, 21 Moyamoya patients are classified into four groups. Results from them suggested that global SvO₂ value may indicate global pathophysiological change supported by reduced SvO₂ without obviously impaired CO₂-CVR and elevated SvO₂ under anesthesia.

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