Longitudinal study of revascularization and BBB disruption after ischemic stroke provides prognostic and therapeutic information. In this work, high resolution UTE-MRAs with superparamagnetic iron oxide nanoparticles (SPION) were performed on a rat tMCAO model to visualize revascularization and BBB disruption longitudinally. UTE-MRAs before and after SPION injection clearly visualized arterial vessels and all vessels, respectively. Thickened and twisted vessels at the rat brain surface of ipsilateral hemisphere were highly resolved (59 μm3 isotropic).
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