Clinical diagnosis based on thoracic blood flow using three-dimensional cardiac-resolved (4D) phase contrast PC-MRI is limited by long acquisition times, due to the need of respiratory gating. In addition, gating does not provide potentially important physiological information, the variation of flow within the respiratory cycle. To address these challenges we developed a 5D (4D respiratory-resolved) PC-MRI sequence combining 3D radial k-space sampling, respiratory self-gating, and compressed sensing reconstruction. Our preliminary results demonstrate respiratory related changes in blood flow in healthy subjects. The proposed method may potentially refine diagnosis in congenital heart disease by assessing the respiratory related blood flow variations.
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