Abstract #4876

Myocardial Oxygenation Using T2* BOLD Cardiac MRI with Compressed SENSE: Association with Myocardial Fibrosis and Contraction in Hypertrophic Cardiomyopathy

Michinobu Nagao¹, Kenji Fukushima¹, Eri Watanabe², Umiko Ishizaki¹, Yuka Matsuo¹, Akiko Sakai², Risako Nakao², Yasuhiro Goto³, Masami Yoneyama⁴, and Shuji Sakai¹

¹Diagnostic Imaging & Nuclear Medicine, Tokyo Women's Medical University, Tokyo, Japan, ²Cardiology, Tokyo Women's Medical University, Tokyo, Japan, ³Radiological service, Tokyo Women's Medical University, Tokyo, Japan, ⁴Philips Electronics Japan, Tokyo, Japan

We developed a new method for myocardial oxygenation using oxygen-inhalation blood-oxygen-level-dependent (BOLD) T2* cardiac magnetic resonance imaging (T2*-CMR). Myocardial oxygenation (ΔR2*, ms-1) was defined as the difference in R2* between under room-air and oxygen inhalation. ΔR2* is increased in patients with hypertrophic cardiomyopathy who had large LGE areas and low strains, suggesting that impairment of myocardial oxygenation associates with myocardial fibrosis and systolic dysfunction. In addition, T2*-CMR with compressed SENSE enables to shorten scan time and less motion artifact. This contributes to make high precision of T2* and R2* maps.

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