Intramyocardial hemorrhage(IMH) and microvascualr obstruction(MVO) were the serious injuries in the early myocardial infarction reperfusion period, which were independent predictors of larger infarct size, lower systolic function and the worse prognosis at follow-up. APT102 as a synthetic apyrase of the hunman nucleoside triphosphate diphosphohydrolase-3(CD39L3) can exhibit ADPase activity, prevent thrombotic reocclusion and decrease infarct size without an increased bleeding risk. The purpose of this study was to continuously detect myocardial ischemia/reperfusion injury and APT102 effect in rats by 7.0T MRI.
This abstract and the presentation materials are available to members only; a login is required.