Abstract #4856

Combined Diffusion Kurtosis Imaging and Dynamic Susceptibility Contrast Magnetic Resonance Perfusion Imaging for In Vivo Molecular Profiling of Human Glioma.

Johann-Martin Hempel¹, Jens Schittenhelm², Nils Nüssle¹, Cornelia Brendle¹, Benjamin Bender¹, Ghazaleh Tabatabai³, Marco Skardelly⁴, Salvador Castaneda Vega⁵, Ulrike Ernemann¹, and Uwe Klose¹

¹Neuroradiology, Eberhard Karls University Tübingen, Tübingen, Germany, ²Neuropathology, Eberhard Karls University Tübingen, Tübingen, Germany, ³Neurology, Eberhard Karls University Tübingen, Tübingen, Germany, ⁴Neurosurgery, Eberhard Karls University Tübingen, Tübingen, Germany, ⁵Preclinical Imaging; Nuclear Medicine, Eberhard Karls University Tübingen, Tübingen, Germany

The purpose of this study was to assess the diagnostic performance of combined DKI and DSC-MRI maps for in vivo assessment of the 2016 WHO integrated glioma grades.

Histogram parameters of DKI show a higher diagnostic performance than those of DSC-MRI in stratifying gliomas according to the integrated molecular approach of 2016 CNS WHO. However, DSC-MRI may provide additional insight into the MGMT methylation profile of primary IDH wild-type GBM. Thus, combined DKI and DSC-MRI provide promising potential biomarkers for glioma.

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