Abstract #4854

True-Diffusion Coefficient Retracted from Intra-Voxel Incoherent Motion (IVIM) Can Stratify Biopsy-Approved Infiltrative Edema from Normal Tissue and Active Tumor in Diffuse Brain Gliomas

Anahita Fathi Kazerooni¹, Nima Gilani¹, Mahnaz Nabil², Mehdi Zeinalizadeh³, Kavous Firouznia⁴, Farid Azmoudeh-Ardalan⁵, Mohammad Peikari⁶, Mohammadreza Alviri¹, Mehrdad Hadavand¹, and Hamidreza Saligheh Rad¹

¹Quantitative MR Imaging and Spectroscopy Group, Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of), ²Department of Statistics, Faculty of Mathematical Science, University of Guilan, Rasht, Iran (Islamic Republic of), ³Department of Neurological Surgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of), ⁴Medical Imaging Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of), ⁵Department of Pathology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of), ⁶Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada

Infiltration of tumorous cells in the normal brain parenchyma is an intrinsic characteristic of diffuse gliomas and is a determinant factor in tumor recurrence, transformation into malignant form, and poor prognosis. The objective of this study was to investigate the role of intra-voxel incoherent motion (IVIM) imaging in characterizing tumor infiltration through localized biopsies. Histopathologically-approved regions of active tumor, infiltrative glioma (edema), and normal tissues were accurately discriminated by true (perfusion-free) diffusion coefficient (D).

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