Abstract #4834

Carotid stenosis: a risk factor for white matter disease even at presymptomatic stage

Pedro Henrique Rodrigues da Silva¹, Ana Paula Afonso Camargo², Antonio Carlos Santos Senra Filho³, Luiz Otavio Murta Junior³, Octávio Marques Pontes Neto², and Renata Ferranti Leoni¹

¹Department of Physics, FFCLRP, University of São Paulo, Ribeirão Preto, Brazil, ²Department of Neurosciences and Behavioral Science, FMRP, University of São Paulo, Ribeirão Preto, Brazil, ³Department of Computing and Mathematics, FFCLRP, University of São Paulo, Ribeirão Preto, Brazil

Studies have suggested that cerebral white matter hyperintensity (WMH) is due to hypertension and is associated with carotid artery stenosis (CAS). However, it is unclear whether this association is attributable to effects on WM and how asymptomatic CAS contributes to it. Therefore, we aimed to assess the association between ACAS and WMH lesions and its relationship with cognitive decline using MRI to provide information that may help predicting cases at risk of brain ischemia. Our data showed that ACAS is associated with WMH lesions and cognitive decline, indicating that ACAS, in addition to age, is likely to cause WM lesions.

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