To conduct a comprehensive assessment of hemodynamics in patients with intracranial atherosclerotic disease (ICAD), an automated analysis tool was developed to quantify 4D flow MRI data, including extraction of pressure gradient and flow resistance across the ICAD stenosis and flow and peak velocity asymmetry indices. For three ICAD cases with identical degree of stenosis, the results demonstrated variability in both flow resistance and flow asymmetry indices. With the inclusion of more patients spanning a spectrum of stenosis degrees, it may be possible to demonstrate the utility of flow resistance as a new metric for characterizing the hemodynamic impacts of ICAD.
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