Abstract #4800

Prominent vessels on quantitative susceptibility maps indicate microvascular pathology after experimental cerebral ischemia and reperfusion

Markus Vaas¹, Andreas Deistung^2,3,4, Jürgen R Reichenbach^2,5, Annika Keller⁶, Anja Kipar⁷, and Jan Klohs¹

¹Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland, ²Institute of Diagnostic and Interventional Radiology, University Hospital Jena, Jena, Germany, ³Department of Neurology, Essen University Hospital, Essen, Germany, ⁴Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, Germany, ⁵Michael Stifel Center for Data-driven and Simulation Science Jena, Friedrich Schiller University Jena, Jena, Germany, ⁶Division of Neurosurgery, University Hospital Zurich, Zurich, Switzerland, ⁷Institute of Veterinary Pathology, University of Zurich, Zurich, Switzerland

We tested the utility of quantitative susceptibility mapping (QSM) to assess vascular abnormalities in a mouse model of experimental stroke. We acquired high resolution gradient echo data of mice at different time points after ischemia/reperfusion for computation of susceptibility maps. Prominent vessels with increased magnetic susceptibility values were detected surrounding the ischemic lesion at all times, indicating an increase in oxygen extraction. Immunohistochemistry revealed narrowed capillaries and dilated larger vessels. Thus, prominent vessels are an important indicator of underlying microvascular pathology and may by pivotal for diagnosis and therapeutic decision making in stroke patients.

This abstract and the presentation materials are available to members only; a login is required.

Join Here