Abstract #4797

Improving Cerebrovascular Reactivity Assessment Using High-Resolution MB-EPI Multi-Delay PCASL Imaging

Xiufeng Li¹, Nicholas Evanoff ², Lynn E. Eberly ³, David Tupper⁴, Anne M. Murray ⁵, Gregory J. Metzger ¹, and Donald R. Dengel ²

¹Center for Magnetic Resonance Research, School of Medicine, University of Minnesota, Minneapolis, MN, United States, ²Laboratory of Integrative Human Physiology, School of Kinesiology, University of Minnesota, Minneapolis, MN, United States, ³Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, United States, ⁴Neuropsychology Section, Hennepin County Medical Center, Minneapolis, MN, United States, ⁵Berman Center for Clinical Research, Hennepin County Medical Center, Minneapolis, MN, United States

Arterial spin labeling (ASL) imaging with a respiratory challenge can provide both quantitative baseline cerebral blood flow and the assessment of the cerebrovascular reactivity (CVR), an index for cerebrovascular function. However, to date, low-resolution and single-delay ASL imaging is primarily applied to assess CVR, and therefore limited. We proposed and successfully applied high-resolution multi-delay pseudo-continuous ASL (PCASL) imaging using a slice accelerated EPI readout for respiratory challenge studies. The study results suggest that the respiratory challenge can induce significant changes in arterial transit time (ATT), and that the estimates of ATT from the multi-delay imaging protocol are critical to achieve unbiased CVR measurements.

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