Abstract #4765

T1-mapping Cardiac-Manganese Enhanced MRI: Assessment of Calcium Homeostasis and Ischemic Injury in Mice

Nur Hayati Jasmin^1,2, Laurence H Jackson³, Thomas A Roberts⁴, Valerie Taylor¹, Mark F Lythgoe¹, and Daniel J Stuckey¹

¹Division of Medicine, UCL Centre for Advanced Biomedical Imaging, London, United Kingdom, ²School of Medical Imaging, Universiti Sultan Zainal Abidin, Terengganu Darul Iman, Malaysia, ³Biomedical Engineering, Kings College London, London, United Kingdom, ⁴Perinatal Imaging & Health, Kings College London, London, United Kingdom

Intracellular MR contrast agents can provide essential information on cell viability. Manganese (Mn²⁺) is an efficient intracellular MR contrast agent. As an analogue of Calcium, Mn²⁺-induced changes in T1 and can be used as an indicator of therate of Ca²⁺ influx into cardiomyocytes in vivo and could provide additional information to that routinely acquired using late Gd-enhanced MRI. By preloaded the myocardium with Mn²⁺ prior to coronary occlusion, we showed that MEMRI T1-mapping allows sensitive in vivo detection of subtle changes and accumulation of Mn²⁺ in viable myocytes in the early phase of myocardial injury.

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