Abstract #4687

Diffusion kurtosis imaging for the diagnosis and prediction of response to treatment in high grade serous ovarian cancer

Surrin Deen¹, Andrew N Priest², Mary A McLean³, Andrew B Gill², Helena Earl², Christine Parkinson², Sarah Smith², Robin Crawford², John Latimer², Peter Baldwin², Helen Addley², Susan Freeman², Charlotte Hodgkin², Ilse Patterson², Mercedes Jimenez-Linan ², James Brenton^2,3, and Ferdia Gallagher^1,2

¹Department of Radiology, University of Cambridge, Cambridge, United Kingdom, ²Addenbrooke's Hospital, Cambridge, United Kingdom, ³Cancer Research UK, Cambridge, United Kingdom

Diagnosis of high grade serous ovarian cancer (HGSOC) requires a biopsy which is both invasive and does not reflect the heterogeneity of the disease. Diffusion kurtosis imaging (DKI) was performed on 23 treatment naïve ovarian cancer patients. Both mean Dapp (apparent diffusion) and mean Kapp (apparent kurtosis) were found to be significantly different in HGSOC compared to other types of epithelial cancer. Kapp was also significantly greater in the patients who went on to respond to chemotherapy treatment compared to non-responders. DKI may therefore aid in identifying HGSOC and in the selection of the best treatment for individual patients.

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