Abstract #4652

Optogenetically-initiated low frequency dorsal hippocampal activity enhances resting-state fMRI connectivity and visual memory retrieval performance

Russell W. Chan^1,2,3, Eddie C. Wong^1,2, Alex T. L. Leong^1,2, Xunda Wang^1,2, Celia M. Dong^1,2, Karim E. Hallaoui^1,2, Lee W. Lim⁴, and Ed X. Wu^1,2

¹Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China, ²Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China, ³Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States, ⁴School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China

Our recent study demonstrated that low frequency optogenetically-initiated hippocampal activities enhances brain-wide resting-state fMRI connectivity. However, the behavioral consequence of such connectivity enhancement remains unknown. Since hippocampus is known to play a prominent role in memory, we assessed the effects of such connectivity enhancement on short-term and long-term memory. Our experimental results demonstrated that, while low frequency dorsal hippocampus stimulation enhanced interhemispheric fMRI connectivity (in hippocampus, V1, A1 and S1), it also improved the long-term visual memory by enhancing memory retrieval (in contrast to memory encoding) performance.

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