Abstract #4642

Simultaneous acquisition of CBV, CBF and BOLD signals induced by visual stimulations of 1, 4 and 8 Hz under normoxia and hypoxia conditions

Yaoyu Zhang^1,2, Yayan Yin^1,3, Bing Wu^1,4, Yang Fan⁴, and Jia-Ηοng Gao^1,3

¹Center for MRI Research, Peking University, Beijing, China, ²Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China, ³Beijing City Key Lab for Medical Physics and Engineering, Peking University, Beijing, China, ⁴MR Research China, GE Healthcare, Beijing, China

A simultaneous acquisition of VASO, ASL and BOLD signals was employed to measure relative functional changes induced by a block-designed, black-and-white checkerboard visual task containing three stimulus frequencies and two oxygen-level conditions. We report that 1) δCBV, δCBF and δBOLD increase along with visual stimulus frequencies for both oxygen-level conditions; 2) δBOLD, but not δCBV or δCBF, acquired under hypoxia condition is significantly lower than that acquired under normoxia condition for all the three stimulus frequencies. According to Fick’s principle, our results predict increases of oxygen consumption rate among various stimulus frequencies during hypoxia.

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