Abstract #4610

Changes in HCC tumor stiffness post 90Yttrium radioembolization assessed with MR elastography: Early results.

Paul Kennedy^1,2, Sara Lewis^1,2, Octavia Bane^1,2, Stefanie Hectors^1,2, Maxwell Segall¹, Edward Kim², and Bachir Taouli^1,2

¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States, ²Department of Radiology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States

The goal of the current study was to assess the changes in hepatocellular carcinoma (HCC) stiffness using 2D MR elastography (MRE) at baseline and 6 weeks after ⁹⁰Yttrium radioembolization (RE). Preliminary results are presented in 10 patients and show that HCC stiffness and liver stiffness adjacent to the treated lesion are both significantly increased 6w after therapy. Percentage change in tumor stiffness is significantly correlated with degree of tumor necrosis at 6w.

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