Abstract #4591

T1ρ mapping for assessment of fibrosis in renal allografts.

Stefanie Hectors¹, Octavia Bane¹, Paul Kennedy¹, Fadi El Salem², Madhav Menon³, Maxwell Segall¹, Rafael Khaim³, Veronica Delaney³, Sara Lewis^1,4, and Bachir Taouli^1,4

¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Recanati-Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁴Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States

The goal of our study was to assess the utility of T_1ρ measurements for the differentiation between functional and fibrotic renal allografts. We observed a significant increase in T_1ρ in the cortex of fibrotic renal allografts compared to functional allografts. Our results show that T_1ρmay be a suitable biomarker for the assessment of fibrosis in renal allografts, which needs to be verified in a larger cohort of patients.

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