Abstract #4581

Multiparametric MRI for assessment of renal transplant fibrosis: preliminary results.

Octavia Bane^1,2, Stefanie Hectors^1,2, Sonja Gordic^2,3, Paul Kennedy^1,2, Mathilde Wagner^2,4, Rafael Khaim⁵, Veronica Delaney⁵, Madhav Menon⁵, Fadi El Salem⁶, Sara Lewis^1,2, and Bachir Taouli^1,2

¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States, ²Radiology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States, ³University Hospital Zurich, Zurich, Switzerland, ⁴Groupe Hospitalier Pitie-Salpetriere, Paris, France, ⁵Recanati-Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States, ⁶Pathology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States

The goal of our study is to develop a multiparametric MRI (mpMRI) protocol for the assessment of renal transplant fibrosis. Our initial results show decrease of cortical and medullary ADC, cortical D and PF, and increase of cortical T1 in fibrotic allografts compared to functional allografts. We also observed loss of corticomedullary differentiation in ADC and T1 with fibrosis. We conclude that diffusion and T1 measurements are sensitive to renal allograft fibrosis, to be confirmed in a larger study.

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