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Abstract #4574

ADC and perfusion fraction f obtained by IVIM model are markers of maternal and fetal human placenta development in normal pregnancy

Amanda Antonelli1, Silvia Capuani2, Michele Guerreri2,3, Silvia Bernardo1, Carlo Catalano1, and Lucia Manganaro1

1Department of Radiological, Oncological and Pathological Sciences, Policlinico Umberto I Università Sapienza di Roma, Rome, Italy, 2Physics Dpt. Sapienza Roma, CNR ISC Roma Sapienza, Rome, Italy, 3SAIMLAL Department, Morphogenesis & Tissue Engineering, Sapienza University of Rome, Roma, Italy

The purpose was to investigate the potential of IVIM model to quantify diffusion and perfusion in human placenta of normal pregnancy. The relation between Apparent diffusion coefficient ADC, perfusion fraction f and pseudo-diffusion coefficient D* obtained in fetal and maternal placenta with microstructural changes occurring during placenta development was investigated. 30 pregnant women (gestational age, GA range = 19-37w) underwent DW examination with b=0,10,30,50,75,100,150,400,700,1000s/mm2. The Pearson correlations between ADC, D*, f and clinical data (GA, Body-Mass Index and basal Glycaemia) were evaluated. ADCvsGA showed significant positive and negative correlation during the II and III trimester of gestation, respectively.

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