Abstract #4566

Placental Functional Imaging with Endogenous Contrast: Preliminary Comparison of BOLD Effect and ASL FAIR in Rhesus Macaque and Human

Ante Zhu^1,2, Kai D. Ludwig³, Wei Zha², Sydney Nguyen⁴, Thaddeus G. Golos^4,5,6, Ian M. Bird⁵, Dinesh M. Shah⁵, Oliver Wieben^2,3, Sean B. Fain^1,2,3, Scott B. Reeder^1,2,3,7,8, Diego Hernando^2,3, and Kevin M. Johnson^2,3

¹Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ²Radiology, University of Wisconsin-Madison, Madison, WI, United States, ³Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ⁴Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, United States, ⁵Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, United States, ⁶Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, United States, ⁷Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁸Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

Non-invasive MRI techniques are needed to quantify placental perfusion and oxygenation during pregnancy. In this work, we assessed the feasibility and correspondence of T2* mapping and arterial spin labeling (ASL) to evaluate placental oxygen delivery. Six pregnant rhesus macaques and seven pregnant women underwent MRI that included T2* mapping and ASL with flow-sensitive alternating inversion recovery (FAIR). Regions of locally high ASL perfusion signal correlated spatially with the regions of locally maximum T2* in animals and humans. The two imaging techniques with endogenous contrast are promising approaches for the detection of oxygen delivery via the placenta.

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