We
present a systematic approach to characterize
differences in pre- and post-contrast diffusion and perfusion parameters. In addition to measuring ADC
values before and after contrast injection, we extended the mono-exponential
model to incorporate the contribution of pseudo-perfusion to the signal
intensity and evaluated the impact of contrast injection on molecular diffusion
(D) and perfusion fraction (f).
We find in PCa, the coefficient D,
like ADC, was significantly lower on post-contrast as compared to pre-contrast
DWI, while the perfusion fraction coefficient was significantly higher on
post-contrast acquisitions. In PZ, ADC and D
did not differ significantly between post- and pre-contrast acquisitions, but f was significantly higher after
contrast injection.
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