Several hyperpolarized xenon-129 (HXe) MRI techniques have been developed for characterizing lung function through the observation of parenchymal xenon gas uptake, but these methods tend to provide only a snapshot of a steady-state distribution of the xenon signal within the lung parenchyma. In this study, we investigated the feasibility of extracting gas-transport maps from the relative signal changes between two dissolved-phase images captured with different acquisition parameters. We demonstrated how the acquisition parameters of a suitably-designed HXe MRI pulse sequence can be harnessed for tracing pulmonary gas transport processes, and potentially quantifying them at an unprecedented level.
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