Abstract #4469

Clinical Translation of 3D Spiral-IDEAL for Single Breath-hold Imaging of Gas and Dissolved-Phase Hyperpolarized 129Xe in Human Lungs

Brandon Zanette^1,2 and Giles Santyr^1,2

¹Translational Medicine Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada, ²Department of Medical Biophysics, Univeristy of Toronto, Toronto, ON, Canada

Spiral-IDEAL is a fast and efficient technique for imaging dissolved-phase hyperpolarized ¹²⁹Xe in tissue/blood plasma (T/P) and red blood cell (RBC) compartments of the lung. Previously, spiral-IDEAL has been limited to pre-clinical rodent models using multi-breath techniques not suitable for human subjects. In this work we optimize and demonstrate clinical translation of spiral-IDEAL for single breath-hold ¹²⁹Xe imaging of human subjects. We compare and contrast several interleaved imaging strategies. Furthermore, we also demonstrate 3D spiral-IDEAL for simultaneous volumetric imaging of gas, T/P, and RBC compartments.

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