Abstract #4463

High Ventilation Percent on Hyperpolarized Helium-3 MRI is Associated with Reduced One-Year Risk of Asthma Exacerbation

David Mummy^1,2, Wei Zha², Shannon Kehoe³, Guy Olson⁴, Ronald Sorkness^5,6,7, Nizar Jarjour⁶, Mark Schiebler⁸, Loren Denlinger⁶, Michael Evans⁹, and Sean Fain^1,2,8

¹Biomedical Engineering, University of Wisconsin -- Madison, Madison, WI, United States, ²Medical Physics, University of Wisconsin -- Madison, Madison, WI, United States, ³Kinesiology, University of Wisconsin -- Madison, Madison, WI, United States, ⁴Neurobiology, University of Wisconsin -- Madison, Madison, WI, United States, ⁵Pharmacy, University of Wisconsin -- Madison, Madison, WI, United States, ⁶Allergy, Pulmonary & Critical Care Medicine, University of Wisconsin -- Madison, Madison, WI, United States, ⁷Pediatrics, University of Wisconsin -- Madison, Madison, WI, United States, ⁸Radiology, University of Wisconsin -- Madison, Madison, WI, United States, ⁹Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, United States

We assessed the high ventilation percent (HVP) as well as the ventilation defect percent (VDP) on hyperpolarized (HP) ³He MRI and found that both measures were associated with exacerbation in the year following imaging, with the HVP exhibiting the stronger association. Both measures were strong predictors relative to other measures of lung function. These findings suggest that HVP is sensitive to one-year risk of asthma exacerbation and is a potential biomarker of asthma instability.

This abstract and the presentation materials are available to members only; a login is required.

Join Here