Abstract #4441

Combined Ultrafast and Steady State DCE-MRI Differentiates Invasive Breast Cancer Types and Is Associated with Pathological Complete Response to Neoadjuvant Chemotherapy

Meredith Sadinski¹, Natsuko Onishi¹, Katherine Gallagher^1,2, Theodore Hunt¹, Amita Shukla-Dave^1,3, Danny Martinez¹, Brittany Dashevsky^1,4, Elizabeth A Morris¹, and Elizabeth Sutton¹

¹Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ²Lenox Hill Radiology, New York, NY, United States, ³Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ⁴Radiology, University of California, San Francisco, CA, United States

132 patients with invasive breast cancer were imaged with our DCE-MRI protocol incorporating ultrafast, DISCO imaging of early wash-in phase with standard, steady state DCE-MRI. Heuristic and pharmacokinetic metrics were calculated from the DISCO and steady state images and compared between invasive lobular and invasive ductal carcinomas. Bolus Arrival Time was significantly higher in ILC than in IDC. Association of parameters with pathological complete response to neoadjuvant chemotherapy administered after the imaging exam was investigated for a subset of 25 patients. Heterogeneity-related parameters were significantly higher in the pCR group encouraging further investigation into imaging biomarkers predictive of treatment response.

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